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Atova EZ 10/10mg Tablet 1 Strip
Lipid-lowering therapy should be part of a comprehensive approach to reducing atherosclerotic vascular disease risk in individuals with hypercholesterolemia. Medication is recommended alongside dietary modifications when non-drug interventions are insufficient.
- Primary Hyperlipidemia: Atova EZ is prescribed to lower total cholesterol (total-C), LDL cholesterol (LDL-C), apolipoprotein B (Apo B), triglycerides (TG), and non-HDL cholesterol, while increasing HDL cholesterol in patients with primary (heterozygous familial and non-familial) hyperlipidemia or mixed hyperlipidemia.
- Homozygous Familial Hypercholesterolemia (HoFH): Used to lower total-C and LDL-C in patients with HoFH, either as an addition to other cholesterol-lowering treatments (e.g., LDL apheresis) or when such options are unavailable.
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✅ Description:
- Atorvastatin: Reduces cholesterol by inhibiting HMG-CoA reductase, limiting cholesterol production in the liver, and enhancing LDL receptor activity to facilitate LDL removal from the bloodstream.
- Ezetimibe: Lowers cholesterol by inhibiting its absorption in the small intestine via the Niemann-Pick C1-Like 1 (NPC1L1) transporter. This mechanism reduces hepatic cholesterol stores and increases cholesterol clearance from the blood, complementing statin activity.
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✔️ Dosage & Administration
- General Dosage: 10/10 mg to 80/20 mg daily, taken once a day, with or without food. The starting dose is typically 10/10 mg or 20/10 mg, with adjustments based on lipid levels after 2+ weeks.
- Severe LDL-C Reduction Needs (>55% decrease): Start at 40/10 mg daily.
- Homozygous Familial Hypercholesterolemia: 40/10 mg or 80/10 mg daily, alongside other lipid-lowering treatments where available.
- Patients with Liver Impairment: Not recommended for those with active liver disease or unexplained high liver enzyme levels.
- Patients with Kidney Impairment: No dosage adjustment required, but monitoring for muscle-related side effects is advised.
- Pediatrics: Safety and effectiveness not established.
- Geriatrics: No dosage adjustment needed.
✔️ Common side effects include:
- Muscle issues (rhabdomyolysis, myopathy, myalgia)
- Liver enzyme abnormalities
- Abdominal pain
✔️
Drug Interactions:
- Increased myopathy risk when combined with fibric acid derivatives, high-dose niacin, cyclosporine, or strong CYP3A4 inhibitors (e.g., clarithromycin, HIV protease inhibitors, itraconazole).
- Cyclosporine & Gemfibrozil: Should not be used together with Atova EZ.
- Niacin & Atova EZ: Can increase the risk of muscle-related side effects.
- Warfarin Users: Monitor INR levels if taking alongside Atova EZ.
- Oral Contraceptives: May require dosage adjustments due to changes in hormone levels.
- Colchicine & Atova EZ: Caution advised due to potential muscle-related complications.
✔️ Contraindications:
- Active liver disease or unexplained high liver enzyme levels.
- Hypersensitivity to any ingredient in the formulation.
✔️ Pregnancy & Breastfeeding:
- Pregnancy Category X: Not safe for use in pregnancy, as lipid-lowering drugs do not benefit fetal development. Should be discontinued in pregnant women.
- Lactation: Unknown if atorvastatin is excreted in breast milk; caution is advised.
✔️ Precautions & Warnings:
- Muscle Risks: Myopathy, including rhabdomyolysis, has been linked to atorvastatin, especially when used with colchicine. Discontinue treatment if symptoms occur.
- Liver Monitoring: Liver enzyme levels should be checked before and during treatment. Discontinue if severe liver injury occurs.
- Hormonal Interactions: Use caution when combined with drugs affecting steroid hormone levels (e.g., ketoconazole, spironolactone, cimetidine).
✔️ Storage:
Store below 30°C in a dry place, away from light and out of children's reach
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information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
